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CASE REPORT
Year : 2018  |  Volume : 5  |  Issue : 3  |  Page : 34-38

Pemphigus vulgaris: Blistering mucocutaneous disease


1 Final Year Student, Department of Oral Medicine and Radiology, VS Dental College and Hospital, Bengaluru, Karnataka, India
2 Reader, Department of Oral Medicine and Radiology, VS Dental College and Hospital, Bengaluru, Karnataka, India
3 Professor and HOD, Department of Oral Medicine and Radiology, VS Dental College and Hospital, Bengaluru, Karnataka, India
4 Professor, Department of Oral Medicine and Radiology, VS Dental College and Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Harshita Thakur
Department of Oral Medicine and Radiology, VS Dental College and Hospital, Bengaluru - 560 004, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/INPC.INPC_2_18

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Pemphigus is a group of potentially fatal dermatoses with both cutaneous and oral manifestations characterized by the appearance of vesicle or bullae. Their manifestations in the oral cavity often precede those on the skin by many months or may remain as the only symptoms of the disease. Most patients could be initially misdiagnosed. Timely recognition and therapy of oral lesions are critical if treatment is instituted during this time, the disease is easier to control and the chance for early remission of the disorder is enhanced. Topical, systemic or intralesional corticosteroids are the treatment of choice for pemphigus vulgaris. Although the mortality has decreased to <10% since corticosteroids appeared, high doses, and prolonged treatment can cause side effects. They can be prescribed with different immunosuppressive therapy to reduce the cumulative dose of corticosteroids. Among the different immunosuppressive drugs, we find azathioprine, methotrexate, and cyclophosphamide and more recently mycophenolate mofetil.


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